Improving and developing the quality of life of villagers is an important factor to achieve sustainable rural development. But economic sanctions are among the factors that could have a major impact on changing the quality of life of villagers. Therefore, the present study aims to analyze the lived experience of villagers of the impact of economic sanctions imposed on the Islamic Republic of Iran in recent years (2018 to 2020) on the quality of life of villagers in Kashmar. The present study is qualitative research in terms of nature, applied research in terms of purpose. The information required in this study has been collected through literature review, interviews, group discussions. the population of the study includes 72 villagers participated in group discussions. for analyzing the results of group discussions, the grounded theory method was used. The results of findings show sanctions have had two different effects on the quality of life of villagers, one positive effect and the other negative, but the negative effects of sanctions outweigh the positive effects. The negative effects of sanctions on the quality of life of villagers include economic, social and psychological aspects and in general the objective dimension and the mental dimension of the quality of life of the villagers. According to the participants, in addition to sanctions, a set of structural and managerial factors play an important role in minimizing or intensifying the impact of sanctions on the quality of life of villagers.